Opportunity Information: Apply for PAR 22 209
The CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development (UG3/UH3 Clinical Trial Not Allowed) funding opportunity (PAR 22-209) is a National Institutes of Health (NIH) cooperative agreement aimed at moving promising medical countermeasures from early discovery into solid preclinical readiness for chemical emergencies. The program is focused on therapeutics that can reduce or prevent harmful health effects after exposure to toxic chemicals, including agents that could be used deliberately (for example, certain chemical warfare agents) as well as chemicals more likely to appear in accidents or industrial incidents (toxic industrial chemicals), pesticides, and pharmaceutical-based agents. The intent is to strengthen national preparedness by supporting projects that can produce realistic, actionable therapeutic candidates rather than ending at basic research observations.
The scope centers on two connected stages of translational work: validating therapeutic targets and performing preclinical characterization of lead compounds, followed by optimization and proof of activity in animal models that mimic post-exposure treatment scenarios. The award uses the NIH UG3/UH3 phased mechanism, meaning the project begins with an initial UG3 phase and can transition to the UH3 phase only after meeting predefined milestones. In practical terms, the UG3 phase supports activities like confirming that a proposed biological target is truly relevant to the injury caused by the chemical threat, demonstrating that modulating the target produces the desired protective or mitigating effect, and identifying and characterizing initial lead compound(s) with enough supporting data to justify more intensive development. The UH3 phase then supports later early-stage development work, including candidate optimization (such as improving potency, selectivity, formulation, stability, dosing feasibility, or other properties needed for practical use) and in vivo demonstration of activity and efficacy in relevant post-exposure models, consistent with the goal of treating after an exposure has occurred.
A key expectation of this FOA is deliverable-driven progress. By the end of the combined UG3/UH3 project period, the project should produce at least one well-characterized therapeutic candidate. That wording signals the program is not just looking for interesting mechanisms or preliminary hits; it is looking for a candidate with a credible preclinical package that positions it for subsequent advanced development steps, while staying within the FOA's boundaries (notably, clinical trials are not allowed under this announcement).
From an administrative and eligibility perspective, this is a discretionary NIH opportunity using a cooperative agreement, which generally means the NIH will have substantial involvement during the project (for example, through milestone oversight, coordination expectations, or programmatic input typical of cooperative mechanisms). The funding activity category is listed under education, environment, and health, and the opportunity references multiple CFDA numbers (93.113, 93.279, 93.846, 93.853, 93.855, 93.867), reflecting the cross-institute nature often seen in CounterACT-related work. The listed award ceiling is $350,000, and the original closing date provided is 2024-10-17.
Eligible applicants are broad and include many common U.S.-based research and development performers: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The FOA explicitly highlights additional eligible organizational types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it draws clear lines around foreign involvement: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicants, but foreign components, as defined by the NIH Grants Policy Statement, are allowed, which typically means certain project elements can be carried out internationally under the prime award when justified and compliant with NIH policy.
Overall, PAR 22-209 is structured to push chemical threat therapeutics beyond early discovery into disciplined, milestone-based preclinical development, emphasizing target validation, lead identification and characterization, optimization, and in vivo post-exposure efficacy evidence, with the end goal of producing at least one credible, well-documented therapeutic candidate suitable for the next stage of the medical countermeasure pipeline.Apply for PAR 22 209
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development (UG3/UH3 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.279, 93.846, 93.853, 93.855, 93.867.
- This funding opportunity was created on 2022-07-06.
- Applicants must submit their applications by 2024-10-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Multi-Omics for Health and Disease - Disease Study Sites (U01 Clinical Trial Optional) Apply for RFA HG 22 008 Funding Number: RFA HG 22 008 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Multi-Omics for Health and Disease - Data Analysis and Coordination Center (U01 Clinical Trial Not Allowed) Apply for RFA HG 22 010 Funding Number: RFA HG 22 010 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $950,000 |
| Multi-Omics for Health and Disease - 'Omics Production Centers (U01 Clinical Trial Not Allowed) Apply for RFA HG 22 009 Funding Number: RFA HG 22 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,700,000 |
| The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) Apply for RFA OD 22 028 Funding Number: RFA OD 22 028 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
| Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional) Apply for PAR 23 042 Funding Number: PAR 23 042 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Genomic Community Resources (U24 Clinical Trial Not Allowed) Apply for PAR 23 085 Funding Number: PAR 23 085 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Data Repository (U24 - Clinical Trials Not Allowed) Apply for PAR 23 079 Funding Number: PAR 23 079 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed) Apply for PAR 23 078 Funding Number: PAR 23 078 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 004 Funding Number: RFA ES 23 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Medical Scientist Partnership Program (FM1 Clinical Trial Not Allowed) Apply for PAR 23 109 Funding Number: PAR 23 109 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) Apply for PAR 23 139 Funding Number: PAR 23 139 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 23 001 Funding Number: RFA ES 23 001 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) Apply for PAR 23 144 Funding Number: PAR 23 144 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $250,000 |
| Tobacco Regulatory Science (R01 Clinical Trial Optional) Apply for RFA OD 23 017 Funding Number: RFA OD 23 017 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 184 Funding Number: PAR 23 184 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 011 Funding Number: RFA ES 23 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 229 Funding Number: PAR 23 229 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 23 263 Funding Number: PA 23 263 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (U24 Clinical Trial Not Allowed) Apply for PAR 23 237 Funding Number: PAR 23 237 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Early-stage Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed) Apply for PAR 23 236 Funding Number: PAR 23 236 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
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