Opportunity Information: Apply for RFA OH 23 001
The Exploratory/Developmental Grants Related to the World Trade Center Health Program (R21) opportunity (RFA OH 23 001) is a discretionary federal grant program administered by the Department of Health and Human Services through the CDC, with support from NIOSH. It is designed to fund early-stage, innovative research that tests new or nontraditional intervention ideas aimed at improving health outcomes for people connected to the World Trade Center Health Program. The target population includes enrolled WTC responders and certified-eligible WTC survivors who receive medical monitoring and or treatment under Subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010, as later amended. The central theme is intervention research that can reduce risk factors tied to the most common causes of illness and death in this population, with an emphasis on practical approaches that can be sustained over time.
A key feature of this R21 mechanism is its exploratory and developmental nature. Applicants are expected to propose concepts that may have minimal or even no preliminary data, which signals that NIOSH is intentionally encouraging high-potential, earlier-stage intervention ideas rather than requiring mature programs with extensive prior results. Projects should focus on modifiable health behaviors and lifestyle factors that meaningfully shape quality of life and longer-term clinical trajectories, including disease progression and recurrence, survival, adverse events, and other measurable health-related outcomes. Examples of the priority areas described in the announcement include nutrition and diet, sleep hygiene, stress management and positive psychology approaches, physical activity, social connectedness, and preventing or reducing substance misuse. NIOSH also indicates it is seeking a balanced portfolio, meaning it wants a mix of projects and intervention types rather than a narrow concentration in only one topic area.
The opportunity is open to a wide range of applicants across government, education, nonprofit, and private sectors. Eligible organizations include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments as well as other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. In practice, this broad eligibility is meant to attract diverse research teams and settings that can design and test interventions relevant to WTC Health Program members, whether delivered through clinical programs, community partnerships, digital tools, or other implementation channels consistent with the goals of the program.
From a funding and timeline standpoint, the grant uses the R21 funding instrument and is listed under CFDA 93.262. The award ceiling is $500,000, and the agency anticipated making about 8 awards under this announcement. The application due date listed in the source information was December 6, 2022, with electronic submissions due by 5:00 pm Eastern Time on the deadline date. Overall, the announcement signals interest in creative, feasible intervention studies that can be piloted and evaluated in ways that generate early evidence, inform larger follow-on studies, and ultimately improve health and well-being among WTC responders and survivors receiving services through the WTC Health Program.Apply for RFA OH 23 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Exploratory/Developmental Grants Related to the World Trade Center Health Program (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.262.
- This funding opportunity was created on Aug 29, 2022.
- Applicants must submit their applications by Dec 06, 2022 Electronically submitted applications must be submitted no later than 500 pm Eastern Time on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: Exploratory/Developmental Grants Related to the World Trade Center Health Program (R21) (RFA OH 23 001)
What is this grant opportunity?
This opportunity is the Exploratory/Developmental Grants Related to the World Trade Center (WTC) Health Program (R21), identified as RFA OH 23 001. It is a discretionary federal grant program administered by the U.S. Department of Health and Human Services through the CDC, with support from NIOSH.
What is the main purpose of the R21 program described here?
The program is designed to fund early-stage, innovative intervention research that tests new or nontraditional ideas aimed at improving health outcomes for people connected to the WTC Health Program. The emphasis is on practical intervention approaches that can be sustained over time.
Who is the target population for the proposed research?
The target population includes enrolled WTC responders and certified-eligible WTC survivors who receive medical monitoring and/or treatment under Subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010, as amended.
Do projects have to be tied to the World Trade Center Health Program?
Yes. The focus is on interventions intended to improve outcomes for people connected to the WTC Health Program, specifically enrolled responders and certified-eligible survivors receiving monitoring and/or treatment under the applicable law.
What type of research is this grant intended to support?
This R21 mechanism supports exploratory and developmental intervention research. The aim is to pilot creative, feasible interventions and evaluate them in ways that generate early evidence, inform larger follow-on studies, and improve health and well-being for WTC responders and survivors.
Is preliminary data required to apply?
Preliminary data may be minimal or not required. The announcement explicitly signals that NIOSH is encouraging earlier-stage, high-potential intervention ideas rather than requiring mature programs with extensive prior results.
What is the central theme or focus area for interventions?
The central theme is intervention research that can reduce risk factors tied to the most common causes of illness and death in the WTC Health Program population, with an emphasis on modifiable behaviors and lifestyle factors that shape quality of life and longer-term clinical trajectories.
What outcomes or impacts should the interventions aim to influence?
Projects should target measurable health-related outcomes and trajectories, including quality of life and longer-term clinical outcomes such as disease progression and recurrence, survival, adverse events, and other health-related endpoints described or implied in the announcement.
What kinds of intervention topics are considered priorities?
Examples of priority areas described include nutrition and diet, sleep hygiene, stress management and positive psychology approaches, physical activity, social connectedness, and preventing or reducing substance misuse.
Are only those listed topic areas allowed?
The opportunity provides examples of priority areas and emphasizes modifiable health behaviors and lifestyle factors. The announcement also highlights interest in new or nontraditional intervention ideas, suggesting room for creative approaches consistent with the stated goals and target population.
What does it mean that this is an R21 mechanism?
The R21 is characterized here as exploratory and developmental. It is intended for early-stage research that tests innovative intervention concepts and generates early evidence that could support larger future studies.
What does the announcement mean by a "balanced portfolio"?
NIOSH indicates it is seeking a balanced portfolio, meaning it wants a mix of projects and intervention types across the priority areas rather than a narrow concentration in only one topic.
Who can apply for this grant?
The eligibility is broad across government, education, nonprofit, and private sectors. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses.
Are for-profit organizations eligible?
Yes. The eligible applicant types include for-profit organizations other than small businesses, as well as small businesses.
Are nonprofits required to have 501(c)(3) status?
No. The eligibility list includes nonprofits with or without 501(c)(3) status, with the noted condition that they are not institutions of higher education in those nonprofit categories.
What agencies are involved in administering or supporting this opportunity?
The grant is administered by the Department of Health and Human Services through the CDC, with support from NIOSH.
What is the CFDA number for this opportunity?
The opportunity is listed under CFDA 93.262.
What is the maximum award amount (award ceiling)?
The award ceiling is $500,000.
How many awards were anticipated?
The agency anticipated making about 8 awards under this announcement.
What was the application due date and time?
The application due date listed in the source information was December 6, 2022, and electronic submissions were due by 5:00 pm Eastern Time on the deadline date.
How were applications required to be submitted?
Applications were to be submitted electronically by the stated deadline time (5:00 pm Eastern Time).
What kinds of delivery settings or channels are suggested for interventions?
The description suggests interventions could be designed and tested in diverse settings and channels relevant to WTC Health Program members, including delivery through clinical programs, community partnerships, digital tools, or other implementation channels consistent with the program goals.
What is the overall emphasis in evaluating proposed projects?
The announcement emphasizes creative and feasible intervention studies that can be piloted and evaluated to generate early evidence, inform larger follow-on studies, and ultimately improve health and well-being among WTC responders and survivors served by the WTC Health Program.
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