Large Research Projects for Combating Antibiotic-Resistant Bacteria (CARB) (R01) | PA 22 047

Opportunity Information: Apply for PA 22 047

The Large Research Projects for Combating Antibiotic-Resistant Bacteria (CARB) (R01) funding opportunity (PA 22 047) is a discretionary federal grant program in the health area, administered by the Agency for Health Care Research and Quality (AHRQ) under CFDA 93.226. It supports large, full-scale research projects using the R01 mechanism, with the central purpose of generating rigorous evidence and practical solutions to help prevent, detect, manage, and reduce the harms associated with antibiotic-resistant bacteria. In plain terms, this FOA is meant for substantial research efforts that can move the field forward in meaningful ways, typically through well-designed studies, multi-site collaborations, or complex projects that address real-world healthcare delivery challenges connected to antibiotic resistance.

The opportunity is open to a wide range of applicant organizations across the United States and U.S. territories. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; and tribal organizations that are not federally recognized. It also includes public housing authorities/Indian housing authorities and nonprofit organizations both with and without IRS 501(c)(3) status (as long as they are not institutions of higher education when applying under those nonprofit categories). Beyond those standard eligibility categories, the FOA explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal government agencies, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. This broad eligibility is a signal that AHRQ is interested in research that reflects diverse care settings and communities, not just traditional academic medical centers.

At the same time, there are clear restrictions on foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. That means the applicant organization and the work proposed under the award are expected to be based domestically rather than being led or primarily carried out through foreign institutions or overseas components.

Key administrative details provided in the source include an original posting/creation date of October 21, 2021, and an original closing date of October 30, 2026. The listing does not specify an award ceiling or the expected number of awards in the provided data, which suggests applicants would need to consult the full FOA text for budget expectations, typical award sizes, project period ranges, and any AHRQ-specific requirements or preferences for CARB-related R01 projects. Overall, this opportunity is positioned for applicants ready to propose large, methodologically strong research projects that can improve healthcare outcomes and health system performance by addressing antibiotic-resistant bacteria through evidence generation and applied, healthcare-focused research.

• The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Large Research Projects for Combating Antibiotic-Resistant Bacteria (CARB) (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226.
• This funding opportunity was created on 2021-10-21.
• Applicants must submit their applications by 2026-10-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.

Apply for PA 22 047

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