Opportunity Information: Apply for PA 24 177
The Mentored Research Scientist Development Award (K01) is an NIH career development grant designed to help promising researchers move toward full research independence. It provides substantial protected time and financial support for an intensive, closely supervised career development period lasting three to five years. The award is meant for investigators working in biomedical, behavioral, or clinical science, and it emphasizes structured mentoring, targeted training, and a clear plan that helps the candidate build the skills, publication record, and preliminary data needed to compete successfully for independent research funding later on.
A key theme of this particular parent K01 opportunity is that it is intended for research career development that includes independent basic experimental studies with humans. In practice, that means applicants should expect the research component to involve prospective assignment of human participants to conditions or interventions (or other forms of experimental manipulation) in order to understand fundamental biological, behavioral, or related mechanisms. Because this is a mentored mechanism, the proposal is generally expected to show a strong, hands-on mentoring team and an environment that can realistically support the candidate in conducting rigorous human studies while also completing career development activities such as advanced coursework, workshops, technical training, and professional development.
While all participating NIH Institutes and Centers use the K01 to cultivate research independence, the announcement highlights that different NIH components may apply the mechanism in slightly different ways. Some Institutes and Centers use K01 awards to help investigators transition into a new scientific field, giving them time and structured mentoring to retrain and build credibility in a different area. Others may prioritize applicants who have experienced a significant career interruption due to illness or major family responsibilities and need a supported pathway to reestablish research momentum. In addition, some NIH components use the K01 to develop expertise in particular scientific disciplines or priority research areas, so applicants typically need to pay attention to Institute- and Center-specific interests when deciding where the application best fits.
Eligibility is broad and includes many types of U.S.-based organizations. Eligible applicants listed for this opportunity include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education, which are listed separately); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, and U.S. territories or possessions.
At the same time, there are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant organization can include certain well-justified international elements within the project when permitted by NIH policy, even though the applicant institution itself must be domestic.
Administratively, this is an NIH discretionary grant opportunity (Funding Instrument: Grant) under the parent K01 announcement titled “Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required),” Funding Opportunity Number PA-24-177. It is associated with multiple CFDA numbers (including 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.310, 93.313, 93.361, 93.398, 93.865, and 93.866), reflecting participation across different NIH Institutes and Centers. The opportunity was created on April 24, 2024, and the listed original closing date is May 7, 2027. The announcement does not specify an award ceiling or expected number of awards in the provided data, which typically means those details may vary by NIH Institute/Center, budget requests, and available appropriations, and applicants should consult the full NIH posting and Institute-specific guidance when planning a budget and submission strategy.Apply for PA 24 177
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.310, 93.313, 93.361, 93.398, 93.865, 93.866.
- This funding opportunity was created on 2024-04-24.
- Applicants must submit their applications by 2027-05-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH Mentored Research Scientist Development Award (K01) - PA-24-177
What is the Mentored Research Scientist Development Award (K01)?
The K01 is an NIH career development grant meant to help promising researchers progress toward full research independence. It supports an intensive, closely supervised career development period that combines mentored research with structured training and professional development.
What is the main purpose of this K01 parent opportunity?
The purpose is to provide substantial protected time and financial support over a multi-year mentored period so a candidate can build the skills, publication record, and preliminary data needed to successfully compete for independent research funding later on.
How long does the K01 career development period last?
The mentored career development period lasts three to five years.
What scientific areas does this K01 support?
This K01 supports investigators working in biomedical, behavioral, or clinical science.
What is a key theme of this specific K01 announcement (PA-24-177)?
A central theme is that the research career development plan must include independent basic experimental studies with humans. The research component is expected to involve experimental manipulation with human participants to understand fundamental biological, behavioral, or related mechanisms.
Does this K01 require human studies?
Yes. This parent K01 opportunity emphasizes research that includes independent basic experimental studies with humans, which generally implies prospective assignment of human participants to conditions or interventions (or other experimental manipulation) as part of the study design.
What does "independent basic experimental studies with humans" mean in practice?
Based on the opportunity description, applicants should expect the research plan to include prospective assignment of human participants to conditions or interventions (or other forms of experimental manipulation) to investigate fundamental mechanisms (biological, behavioral, or related).
How important is mentoring in this K01 mechanism?
Mentoring is central. As a mentored mechanism, the proposal is generally expected to demonstrate a strong, hands-on mentoring team and an environment that can support both rigorous human studies and structured career development activities.
What kinds of career development activities are expected?
The announcement highlights structured mentoring and targeted training, and it gives examples such as advanced coursework, workshops, technical training, and professional development activities.
What outcomes is the K01 designed to help a candidate achieve?
The K01 is designed to help the candidate build skills, a stronger publication record, and preliminary data, positioning them to compete successfully for independent research funding later.
Do all NIH Institutes and Centers use the K01 in the same way?
No. The announcement notes that different NIH Institutes and Centers may apply the K01 mechanism in slightly different ways, so applicants should pay attention to Institute- and Center-specific interests and priorities.
Can the K01 be used to transition into a new scientific field?
Yes. The announcement indicates that some NIH Institutes and Centers use K01 awards to help investigators transition into a new scientific field by providing time and structured mentoring for retraining and credibility-building.
Does the K01 support researchers returning after a career interruption?
It can. The announcement states that some NIH components may prioritize applicants who have experienced significant career interruptions due to illness or major family responsibilities and need support to reestablish research momentum.
Are there Institute- or Center-specific priority areas that could affect fit?
Yes. The announcement explains that some NIH components use the K01 to develop expertise in particular disciplines or priority research areas, so choosing the best NIH Institute/Center fit can matter.
What types of organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations. Eligible applicants listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits (with or without 501(c)(3) status, as long as they are not institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are minority-serving and other specified institution types eligible?
Yes. The announcement explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The opportunity listing explicitly calls out faith-based or community-based organizations as eligible applicant categories.
Can federal government agencies apply?
Yes. The eligible applicant categories include eligible agencies of the federal government.
Are U.S. territories or possessions eligible to apply?
Yes. The eligible applicant categories include U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply as the applicant organization?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization for this opportunity.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
Are any international elements allowed within the project?
Yes, in certain cases. While the applicant institution must be domestic, "foreign components" are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant organization may include well-justified international elements when permitted by NIH policy.
What is the funding instrument for this opportunity?
The funding instrument is a discretionary grant (Funding Instrument: Grant).
What is the Funding Opportunity Number (FON) for this parent announcement?
The Funding Opportunity Number is PA-24-177.
What is the title of the parent announcement?
The parent announcement is titled "Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required)."
When was this opportunity created?
The opportunity was created on April 24, 2024.
What is the original closing date listed for this opportunity?
The listed original closing date is May 7, 2027.
Does the provided information include an award ceiling?
No. The provided information does not specify an award ceiling. The description notes that this often means details can vary by NIH Institute/Center, budget requests, and available appropriations.
Does the provided information include the expected number of awards?
No. The provided information does not state the expected number of awards, and it notes that those details may vary by NIH Institute/Center and available appropriations.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers, including 93.113, 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.310, 93.313, 93.361, 93.398, 93.865, and 93.866. This reflects participation across different NIH Institutes and Centers.
Why are there multiple CFDA numbers listed?
Multiple CFDA numbers are listed because multiple NIH Institutes and Centers participate in the parent K01 opportunity, and those components may map to different CFDA program areas.
What should applicants do about NIH Institute/Center fit and budgeting based on the information provided?
The description indicates that Institute/Center priorities and budget-related details can vary, and it suggests consulting the full NIH posting and Institute-specific guidance when deciding fit, planning a budget, and developing a submission strategy.
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