Opportunity Information: Apply for PA 16 388

The National Institutes of Health (NIH) offered this discretionary grant opportunity under Funding Opportunity Announcement (FOA) PA 16-388, titled "Research on Autism Spectrum Disorders (R01)." It uses the NIH R01 mechanism, which is the standard research project grant designed to support a well-defined, investigator-initiated research plan. The overall aim of the FOA is to stimulate rigorous research that improves understanding of autism spectrum disorders (ASD) across the full pipeline from causes and population patterns to clinical identification and real-world care.

The scientific scope is broad and centered on generating evidence that can clarify ASD etiology (the underlying causes and contributing factors), epidemiology (prevalence, incidence, risk factors, and trends across populations), diagnosis (including approaches that improve detection, characterization, and differential diagnosis), treatment (pharmacological, behavioral, psychosocial, and other interventions), and service delivery (how to organize, deliver, and optimize supports and care in practical settings). In plain terms, NIH is looking for projects that can help explain why ASD develops, how it presents across different groups, how to identify it more accurately and earlier, what interventions are most effective for which individuals, and how systems like clinics, schools, and community programs can provide services in ways that actually work for people and families.

Eligibility is intentionally expansive to encourage diverse institutions and partnerships. Eligible applicants include many types of U.S. government entities (state, county, city or township, special district governments), independent school districts, and public housing authorities/Indian housing authorities. Academic applicants can include public and state-controlled institutions of higher education as well as private institutions of higher education. The FOA also allows nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. NIH also lists additional eligible applicants that reflect an emphasis on inclusion and community reach, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). Faith-based or community-based organizations may apply, as can eligible federal agencies, regional organizations, U.S. territories or possessions, and certain tribal governments and tribal organizations, including Indian/Native American Tribal Governments that are not federally recognized. Notably, the FOA permits applications from non-domestic (non-U.S.) entities, meaning foreign organizations can also be eligible, which can support international collaborations or studies involving non-U.S. populations when scientifically justified.

From an administrative standpoint, the opportunity is categorized as a grant in the Environment, Health, Income Security and Social Services funding activity area, and it is associated with CFDA numbers 93.113, 93.173, 93.242, 93.853, and 93.865. The FOA record shows a creation date of August 5, 2016, and an original closing date listed as November 30, 2017. The listing does not specify an award ceiling or the expected number of awards in the provided source data, which typically means applicants would need to consult the full FOA text and NIH Institute/Center participation to understand likely budget ranges, project periods, and funding levels. Overall, this R01 announcement is designed to fund substantive, hypothesis-driven or well-justified research projects that can move the field forward on understanding ASD and improving outcomes through better diagnosis, more effective interventions, and stronger service delivery systems.

  • The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Research on Autism Spectrum Disorders (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.242, 93.853, 93.865.
  • This funding opportunity was created on 2016-08-05.
  • Applicants must submit their applications by 2017-11-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH FOA PA 16-388 - Research on Autism Spectrum Disorders (R01)

What is this funding opportunity?

This is a discretionary research grant opportunity from the National Institutes of Health (NIH) under Funding Opportunity Announcement (FOA) PA 16-388, titled "Research on Autism Spectrum Disorders (R01)."

What grant mechanism does this opportunity use?

The opportunity uses the NIH R01 mechanism, which is NIH's standard research project grant intended to support a well-defined, investigator-initiated research plan.

What is the overall goal of FOA PA 16-388?

The overall aim is to stimulate rigorous research that improves understanding of autism spectrum disorders (ASD) across the full research and implementation pipeline, including causes and population patterns, clinical identification, and real-world care.

What autism-related topics does NIH want this FOA to address?

The FOA has a broad scientific scope and centers on generating evidence across multiple areas, including ASD etiology, epidemiology, diagnosis, treatment, and service delivery.

What kinds of research are included under ASD etiology in this FOA?

Projects may focus on the underlying causes of ASD and contributing factors that help explain why ASD develops.

What does NIH mean by ASD epidemiology in this opportunity?

Epidemiology in this FOA includes research on prevalence, incidence, risk factors, and trends across populations.

What types of diagnostic research fit this announcement?

Diagnostic research can include approaches that improve detection, characterization, and differential diagnosis of ASD, including efforts aimed at identifying ASD more accurately and earlier.

What types of treatment research are within scope?

The FOA includes treatment research across pharmacological, behavioral, psychosocial, and other intervention approaches, with the goal of determining what interventions are most effective and for which individuals.

What is meant by service delivery research for ASD?

Service delivery research focuses on how to organize, deliver, and optimize supports and care in practical settings such as clinics, schools, and community programs, emphasizing approaches that work in real-world conditions for people and families.

Does the FOA encourage research that connects discovery to real-world care?

Yes. The stated intent spans the full pipeline from causes and population patterns to clinical identification and real-world care, indicating interest in research that can translate into improved outcomes through better diagnosis, more effective interventions, and stronger service delivery systems.

Who is eligible to apply?

Eligibility is intentionally broad and includes a wide range of U.S. and non-U.S. entities, spanning government, education, nonprofit, for-profit, and tribal organizations, as well as certain designated institution types.

Are U.S. state and local government entities eligible?

Yes. Eligible applicants include U.S. government entities such as state, county, city or township, and special district governments.

Are independent school districts eligible?

Yes. Independent school districts are listed as eligible applicants.

Are public housing authorities eligible?

Yes. Public housing authorities and Indian housing authorities are included as eligible applicants.

Are colleges and universities eligible?

Yes. Academic applicants may include public and state-controlled institutions of higher education as well as private institutions of higher education.

Are nonprofit organizations eligible?

Yes. Nonprofit organizations both with and without 501(c)(3) status may apply, as long as they are not institutions of higher education (per the eligibility description provided).

Are for-profit organizations eligible?

Yes. For-profit organizations (other than small businesses) are listed as eligible applicants, and small businesses are also listed as eligible.

Are small businesses eligible to apply?

Yes. Small businesses are explicitly included among the eligible applicants.

Are minority-serving institutions specifically encouraged or eligible?

Yes. The FOA lists multiple categories of institutions that reflect an emphasis on inclusion and community reach, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations may apply.

Can federal agencies apply?

Yes. Eligible federal agencies are included among eligible applicants.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed as eligible applicants.

Are tribal governments and tribal organizations eligible?

Yes. Certain tribal governments and tribal organizations are eligible, including Indian/Native American Tribal Governments that are not federally recognized.

Can non-U.S. (foreign) organizations apply?

Yes. The FOA permits applications from non-domestic (non-U.S.) entities, meaning foreign organizations can be eligible, which can support international collaborations or studies involving non-U.S. populations when scientifically justified.

What is the funding activity area for this grant?

The opportunity is categorized in the Environment, Health, Income Security and Social Services funding activity area.

Which CFDA numbers are associated with this opportunity?

The FOA is associated with CFDA numbers 93.113, 93.173, 93.242, 93.853, and 93.865.

When was the FOA record created?

The FOA record shows a creation date of August 5, 2016.

What is the closing date listed for this opportunity?

The original closing date listed in the provided information is November 30, 2017.

Does the provided information list an award ceiling?

No. The provided source data does not specify an award ceiling.

Does the provided information state the expected number of awards?

No. The expected number of awards is not specified in the provided source data.

Where would applicants typically look for budget ranges, project periods, and funding levels?

Based on the information provided, applicants would typically need to consult the full FOA text and NIH Institute/Center participation to understand likely budget ranges, project periods, and funding levels.

What kind of projects is this R01 announcement designed to fund?

This R01 announcement is designed to fund substantive, hypothesis-driven or well-justified research projects that can move the field forward in understanding ASD and improving outcomes through better diagnosis, more effective interventions, and stronger service delivery systems.

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